Recombinant DNA Research: must be done in accordance with the current edition of the NIH Guidelines for Research Involving Recombinant and Synthetic Nucleic Acid Molecules.

Infectious Agent Research must be done following the NIH/CDC publication Biosafety in Microbiological and Biomedical Laboratories.

In addition, any substantive changes in procedures or type of recombinant and synthetic nucleic acid molecules/infectious agents should be reported to the IBC through an amendment to the active registration. This also includes changes in key personnel, laboratories, or other modifications to the active registration. An Annual Renewal and Modification Form must be submitted each year for each approved registration. A new registration document must be completed every three years. The allowance of a grace period would be out of compliance with National Institutes of Health and institutional policy.

The investigator should also be aware that doing work on an expired registration is a violation of NIH grants policy as well as the pertinent NIH regulations governing the specified research and would constitute a significant issue of non-compliance. Significant issues of non-compliance are reportable to the NIH and to the relevant funding section.

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