Associate Professor

Year Started at JMU: 1999

rifetk@jmu.edu

Contact Info

Research Description

Neurodegenerative diseases like Alzheimer's and Parkinson's disease are characterized by misfolded proteins. Many of these proteins when not misfolded have nuclear functions--binding to DNA, regulating transcription, and protecting the DNA against double strand breaks. My research lab uses a variety of molecular techniques to further our understanding of the nuclear role of these proteins in non-diseased tissue and the consequences of protein misfolding in diseased neurons.

Courses
  • Cell and Molecular Biology (214)
  • Allied Health Microbiology (BIO 280)
  • Advanced Molecular Biology (BIO 480)
Education
  • PhD in Biochemistry, 1998, Ohio State University
  • MS in Biochemistry, 1992, Michigan State University
Select Publications
  • T. Rife, B. Rasoul*; N. Pullen*; D. Mitchell*; K. Grathwol*; and J. Kurth;, “The Effect of a Promoter Polymorphism on the Transcription of Nitric Oxide Synthase I and its Relevance to Parkinson’s Disease,” Journal of Neurological Science, (2009)
  • T. K. Rife, J. Xie, C. Redman* and A. P. Young, "NGF-mediated Induction of Nitric Oxide Synthase 1 Luciferase Fusion Genes Stably Transformed into PC12 Cells," Brain Research. Molecular Brain Research, vol. 75 pp.225-236, (2000)
    *undergraduate student author

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