Professor of Biology
B.S. - James Madison University
Ph.D. - Wake Forest University

Phone - 540-568-6333
Fax - 540-568-3333
Offices - Bioscience 2028B

Office Hours    |    Personal web page

Courses:   Human Anatomy (BIO 290), Functional Neuroscience for Occupational Therapists (BIO 440/540), Clinical Anatomy for Occupational Therapists (BIO 414/514), Human Histology (BIO 482/582), Advanced Human Anatomy (BIO 410), Scientific Presentations (BIO 603)

Research Interest: Development of the Auditory System

Hearing is one of our most important senses and is ultimately the responsibility of the auditory system. Processing that occurs within the central auditory system enables us to unconsciously sort out meaningful sounds from background noise, to localize the source of sounds, and to determine whether a sound is noteworthy of our attention. These sophisticated auditory tasks that we perform routinely depend upon specialized neural circuits that compute subtle differences in the shape, timing, and intensity of stimuli as they arrive at each ear.

The circuitry underlying such complex auditory processing requires an elaborate organization. An ordered arrangement of inputs to an auditory center is essential since it not only preserves information that has been processed downstream, but it also provides the foundation for a neural network that is capable of integrating that information before it is relayed on to the next level of the system. The focus of my research laboratory is to elucidate the mechanisms that establish frequency-specific circuits in the auditory system prior to experience. To accomplish this, we utilize a combination of neuroanatomical, cell culture, and molecular approaches to explore how a family of signaling molecules (Eph-ephrins) influences auditory circuit formation. Additionally, we perform a variety of physiological and behavioral assessments in control and transgenic mice to determine the functional importance of these guidance molecules. Insights gained from our research are clinically relevant as they may help guide new treatment strategies for the hearing impaired and those suffering from tinnitus, as well as being directly applicable to the fields of plasticity, recovery, and regeneration.

Dillingham CH, Gay SM, Behrooz R, Gabriele ML. 2017. Modular-extramodular organization in developing multisensory shell regions of the mouse inferior colliculus. J Comp Neurol. 525(17):3742-3756.

Wallace MM, Harris JA, Brubaker DQ, Klotz CA, Gabriele ML. 2016. Graded and discontinuous EphA-ephrinB expression patterns in the developing auditory brainstem. Hearing Research. 335:64-75.

Cramer KS, Gabriele ML. 2014. Axon guidance in the auditory system: Multiple functions of Eph receptors. Neuroscience (Forefront Review). 277:152-162.

Liuzzo AM, Gray LC, Wallace MW, Gabriele ML. 2014. Effects of Eph-ephrin mutations on pre-pulse inhibition in mice. J Physiol & Behavior. 135:232-236.

Wallace MM, Kavianpour SM, Gabriele ML. 2013. Ephrin-B2 reverse signaling is required for topography but not pattern formation of lateral superior olivary inputs to the inferior colliculus. J Comp Neurol. 521(7)1585-1597.

Gabriele ML, Brubaker DQ, Chamberlain KA, Kross KM, Simpson NS, Kavianpour SM. 2011.  EphA4 and eprhin-B2 expression patterns during inferior colliculus projection shaping prior to experience.  Developmental Neurobiology. 71:182-199.

Fathke RL, Gabriele ML. 2009. Patterning of multiple layered projections to the auditory midbrain prior to experience.  Hearing Research. 249:36-43.

Gabriele ML, Shahmoradian SH, French CC, Henkel CK, McHaffie JG.  2007.  Early segregation of layered projections from the lateral superior olivary nucleus to the central nucleus of the inferior colliculus in the neonatal cat.  Brain Research. 1173:66-77.

Gabriele ML, Smoot JE, Jiang H, Stein BE, and McHaffie JG. 2006.  Early establishment of adult-like nigrotectal architecture in the neonatal cat: A double labeling study using carbocyanine dyes.  Neuroscience 137(4):1309-1319.  

Henkel CK, Gabriele ML, McHaffie JG.  2005.  Quantitative assessment of developing afferent patterns in the cat inferior colliculus revealed with calbindin immunohistochemistry and tract tracing methods.  Neuroscience 136(3):945-955.

McHaffie JG, Anstrom KK, Gabriele ML, and Stein BE. 2001. Distribution of the calcium binding proteins calbindin D-28k and parvalbumin in the superior colliculus of adult and newborn cat and rhesus monkey. Exp Brain Res 141:460-470.

Gabriele ML, Brunso-Bechtold JK, and Henkel CK. 2000. Plasticity in the development of afferent patterns in the inferior colliculus of the rat after unilateral cochlear ablation. J Neuroscience 20(18):6939-6949.

Gabriele ML, Brunso-Bechtold JK, and Henkel CK. 2000. Development of afferent patterns in the inferior colliculus of the rat: Projection from the dorsal nucleus of the lateral lemniscus. J Comp Neurol 416:368-382.

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