Courses:
Principles of Animal Development (BIO
316), Comparative
Morphology and Evolution of the Vertebrates (BIO 320), Biology in the
Movies (HON 200X), Evolutionary and Societal Impacts of Developmental
Biology (BIO 450), Scientific
Perspectives (GSCI 104)
Research Interests: The role of hormones in the
development and evolution
of
amphibians.
My research is on the role of hormones in the
development and evolution of
amphibians. I am interested specifically in their metamorphosis, which
is a
dramatic change in body form that is regulated by thyroid hormone (TH)
and
results in remarkable variation in skeletal anatomy.
The question of current interest is how do similar
tissues in a frog skull
respond to TH in different ways. One aspect of this project is to
survey the
mouth and throat skeleton of Xenopus laevis frogs at metamorphic stages
to map
out the patterns of cell proliferation and cell death in the different
cartilages. A second is to transplant neural crest cells between frog
embryos
to form tadpoles with extra skeletal elements in new parts of the head,
, e.g.
a jaw cartilage in place of a gill arch cartilage, and then monitor how
these
cartilages respond to TH. A third aspect is to modify the pattern of
Hox gene
expression in one cartilage to transform its larval shape and then see
whether
its TH response has also been affected. The ultimate goal is to
understand not
only how TH responses are specified in frog cartilages but how these
responses
may be altered in evolution to produce different remodelling pathways
in
different species. The research techniques range from rearing amphibian
larvae
to osteological and morphometric analyses, in situ hybridization,
immunohistochemistry, tissue grafting and cell injection.
Selected
Publications:
Rose, C.S. 2007. Biology in the movies: Using the
double-edged sword of popular culture to enhance public understanding
of science. Evol. Biol. 34: 49-54.
Wang, Y. and C.S. Rose. 2005. Jeholotriton paradoxus (Amphibian:
Caudata) from the Lower Cretaceous of
Southeastern Inner Mongolia, China. J. Vertebrate Paleontol. 25(3):
523-532.
Rose, C.S. 2005. Integrating ecology and
developmental biology to
explain the timing of frog metamorphosis. Trends in Ecology and
Evolution 20: 129-135.
Rose, C.S. 2003.
Thyroid hormone
mediated development in vertebrates: What makes frogs unique? In: Environment,
Development and Evolution, Toward a Synthesis, G. B.
Müller, B. K.
Hall, R. D. Pearson, eds. Vienna Series in Theoretical Biology.
Cambridge: MIT
Press, pp. 197-237.
Rose, C.S. 2003. The developmental morphology of
salamander skulls. In:
Amphibian Biology, Vol. 5. Osteology, H.
Heatwole and M Davies, ed., Australia: Surrey Beatty and Sons Pty.
Ltd., pp.
1686-1783.
Rose, C.S. 2003.
How to teach biology using the movie science of cloning
people, resurrecting the dead, and combining flies and humans. Public
Understand. Sci. 12: 289-296.
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