James Madison University

Project Title:

The hemodynamics of a mechanical and a biological prosthetic heart during healthy and diseased cardiac flow conditions using particle image velocimetry.

Project Team:

  • Dr. Olga Pierrakos (Department of Engineering)
  • Kritika Vayur (Engineering, ‘13)

Project Description:

Kritika Vayur (’13) partnered with Dr. Olga Pierrakos on a comparative in-vitro study on the hemodynamics of a mechanical and a biological prosthetic heart during healthy and diseased cardiac flow conditions using particle image velocimetry.  A powerful heart stimulation machine and a and a state-of-the-art experimental technique, Time-Resolved Digital Particle Image Velocimetry (TRDPIV), were used to quantify the downstream flow past two heart valves (one mechanical and one biological) in the mitral position. TRDPIV provides an estimate of shear stresses, turbulence levels, vortical characteristics, etc.  By changing the heart rate and stroke volume, both normal and diseased cardiac conditions and flows were stimulated.  Results from such a project can impact prosthetic heart valve designs, assessment methods for evaluating heart valve performance, development of diagnostic measures for evaluating cardiac performance, etc.