I studied the unfolded protein response of C. elegans in the absence of the nascent polypeptide-associated complex (NAC). The NAC is a chaperone protein complex necessary for the proper folding and localization of proteins during translation. I specifically investigated the effects of NAC-depletion on the expression of heat-shock proteins Hsp-60 and Hsp-4. Using Hsp-gfp fusion proteins, I measured the upregulation of these heat shock proteins after depleting NAC by RNA interference. The work was a continuation of a project described in this paper we recently published.

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