Deadline: February 5, 2018

Agency/Sponsor: National Institutes of Health

Website: https://grants.nih.gov/grants/guide/pa-files/PAR-17-306.html

The purpose of this program is to fund highly innovative and promising research that tests multi-level physical activity intervention programs acting on at least two levels of the socio-ecological model and designed to increase health-enhancing physical activity: 1) in persons or groups that can benefit from such activity; and 2) that could be made scalable and sustainable for broad use across the nation. The proposed intervention must include physical activity change as a primary outcome and be designed to test statistically significant differences in the outcome based on the intervention over the 1-2 year intervention period.  Secondary outcomes of interest include: persistent post-treatment conditions or toxicities affecting physical and cognitive function, cardiorespiratory fitness, skeletal-muscle and bone health, substance abuse, smoking cessation,  cognition and memory,  age-related chronic conditions/multi-morbidities, cardiovascular disease, prevention of secondary conditions (such as decrement in skeletal muscle strength and functioning,  decline in bone and joint health) as they impact rehabilitation outcomes (reduced impairment, improved function, or reduced disability), inflammation, insulin resistance, sex hormones, insulin or insulin-like growth factors or their binding proteins, glucose metabolism, leptin and other adipokines, immunologic or inflammatory factors, oxidative stress and DNA damage or repair capacity, angiogenesis, or prostaglandins, dyslipidemia, dysglycemia, atherosclerosis, and obesity.  Where inclusion of obesity as secondary outcome occurs, the intervention should principally aim to improve physical activity or reduce sedentary behavior and include rationale for health benefit independent of weight loss.

The maximum project period is 5 years and budgets should reflect the actual needs of the proposed project.



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