A-to-Z Index

Debbie Mohler

Debbie Mohler, Ph.D.

Director, Biotechnology Program
Associate Professor
Department of Chemistry and Biochemistry
540.568.8803
mohlerdl@jmu.edu
Group Website

Education, Honors, Awards

  • Director, Biotechnology Program (2010-present)
  • Associate Professor of Chemistry and Biochemistry (2008-present)
  • Assistant Professor of Chemistry and Biochemistry (2005-2008)
  • Phi Beta Kappa faculty honoree (2004)
  • Mortarboard Society faculty honoree (2003)
  • NSF CAREER Award (1997-2001)
  • Ph.D. University of California at Berkeley (1992)
  • B.S. College of William and Mary (1985)

Research Interests

  • Investigation of chromatin structure by DNA footprinting in vivo
  • DNA cleaving agents
  • Synthesis of siRNA analogs
  • Preparation of organic and organometallic dyes for interfacial electron transfer studies in model solar energy systems

Research Description

please see group webpage linked above

Selected Recent Publications

  • Chen, D.; De, R.; Mohler, D. L., “A facile synthesis of thioalkyl- and di(thioalkyl)-substituted bipyridines,” Synthesis, 2009, 211-216.
  • Huang, J.; Stockwell, D.; Huang, Z.; Mohler,  D. L.; Lian, T. “Photoinduced Ultrafast Electron Transfer from CdSe Quantum Dots to Re-bipyridyl Complexes,” J. Am. Chem. Soc. 2008130,  5632-5633. 
  • Mohler, D. L.; Downs, J. R.; Coonce, J. G.; Mirandi, J. L.; Riera, L.; Reira, V.; Pérez, J. “Dual Mechanisms of DNA Damage by MoX(h3-allyl)(CO)2(phen) Complexes,” J. Org. Chem. 2007, 72, 8755-8759.
  • Maddox, M. P. III; Colton, C. M., Patterson, M. J.; Mohler, D. L. “Dissociation of DNA-Histone Assemblies Resulting from Protein Side-Chain Functionalization,” J. Am. Chem. Soc. 2007, 129, 11328-11329.
  • Shell, T. A.; Glass, J., Mackey, M. A.; Layman, K. A.; Mohler, D. L., “Formal DNA Hydrolysis by Mono- and Dinuclear Iron Complexes” Inorg. Chem. 2007, 46, 8120-8122.
  • Shell, T. A.; Mohler, D. L., “Hydrolytic DNA cleavage by non-lanthanide metal complexes,” Curr. Org. Chem., 2007, 11, 1525-1542.
  • She, C.; Guo, J.; Irle, S.; Morokuma, K.; Mohler, D. L.; Zabri, H.; Odobel, F.; Youm, K.-T.; Liu, F.; Hupp, J. T.; Lian, T., "Comparison of Interfacial Electron Transfer through Carboxylate and Phosphonate Anchoring Groups, " J. Phys. Chem. A 2007, 111, 6832-6842.
  • Mohler, D. L.: Kumaraswamy, S.; Stanger, A.: Vollhardt, K. P. C., “1,2,3,4-Tetraethynylbenzene as a Template for Cobalt-catalyzed Alkyne Co-cyclizations: Synthesis of 2,3,8,9-Tetrakis(trimethylsilyl) Angular [3]Phenylene and Bent [5]Phenylene (Benzo[1'',2'':3,4;3'',4'':3',4']dicyclo-buta[1,2-b:1',2'-b']bisbiphenylene),” Synlett 2006, 2981-2984.
  • Mohler, D. L.; Shen, G., “The Synthesis of Tethered Ligand Dimers for PPARg-RXR Protein Heterodimers,” Org. Biomol. Chem. 2006, 4, 2082-2087.
  • Mohler, D. L.; Downs, J. R.; Hurley-Predecki, A. L.; Sallman, J. R.; Gannett, P. M.; Shi, X., “DNA Cleavage by the Photolysis of Cyclopentadienyl Metal Complexes: Mechanistic Studies and Sequence Selectivity of Strand Scission by CpW(CO)3CH3,” J. Org. Chem. 2005, 70, 9093-9102 (featured on journal cover).
  • She, C.; Anderson, N. A.; Guo, J.; Liu, F.; Goh, W-H.; Chen, D.; Mohler, D. L.; Tian, Z.-Q.; Hupp, J. T.; Lian, T., “pH-Dependent Electron Transfer from Molecules to Metal Oxide Nanocrystalline Thin Films, J. Phys. Chem. B, 2005, 109, 19345-19355.
  • Mohler, D. L.; Shell, T. A., “The hydrogen peroxide induced enhancement of DNA cleavage in the ambient light photolysis of CpFe(CO)2Ph: a potential strategy for targeting cancer cells,” Bioorg. Med. Chem. Lett. 2005, 15, 4585.
  • Shell, T. A.; Mohler, D. L., “Selective targeting of DNA for cleavage within DNA-histone assemblies by a spermine-[CpW(CO)3Ph]2 conjugate,” Org. Biomol. Chem. 2005, 3, 3091.