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Department of Chemistry- LC/MS Facility


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lc ms lab tof lcms sample
Point of Contact: Christine Hughey (540-568-6633)

The JMU liquid chromatography/mass spectrometry (LC/MS) undergraduate research facility, housed within the Department of Chemistry & Biochemistry, was established in 2010 with two Major Research Instrumentation (MRI) grants from the National Science Foundation.

The LC/MS instruments housed in the facility include: (1) an Agilent 6460 triple quadrupole (QQQ) mass spectrometer coupled to two Rapid Resolution LC pumps and a diode array detector, (2) an Agilent 6224 time of flight (TOF) mass spectrometer coupled to an Infinity UHPLC pump, and (3) an Agilent 6530 quadrupole time of flight (q-TOF) mass spectrometer coupled to an Infinity UHPLC pump.  All three instruments are equipped with an electrospray source.  The time of flight instruments afford the high mass accuracy and high resolution necessary for identification of unknowns in complex mixtures.  The MS/MS capability of the q-TOF affords additional structural information.  The sensitivity of the QQQ makes this instrument ideal for small molecule quantitation.  Together, these three instruments provide a robust platform for the qualitative and quantitative analysis of biological and environmental samples.