Associate Professor of Biology
B.S. - Appalachian State University
Courses: Organisms Lab (BIO 114), Human Anatomy (BIO 290), Human Embryology (BIO 416), Scientific Presentations (BIO 603)
Chronic wounds (ulcers) compromise the health and quality of life for millions of people in the United States suffering from various diseases (e.g., diabetes) and disabilities (e.g., paralysis). Although chronic wounds develop for many reasons, they are thought to persist due to an imbalance of growth factors, enzymes, and enzyme inhibitors secondary to decreased blood flow. My lab uses cell and molecular biology techniques to identify relevant protein and mRNA levels within the wound before and after treatment. Ultimately, I hope to develop a simple and inexpensive assay to assist the clinician in assessing the efficacy of the chosen treatment prior to observing visual changes in wound health. Such information will benefit patients with chronic wounds, the clinicians’ choice of intervention, and the economics associated with treatment. Students working in my lab will have the opportunity to acquire commonly used cell and molecular biology techniques and to use these techniques to answer questions regarding the biochemistry of healing and nonhealing wounds.
Jaynes CD, Fries K, Brogan MS, Karch JE, Baird K, Edsberg LE. Development of a protocol for biochemical analysis of wound fluid proteins. Acute Care Perspectives, 12:1 (2003) 11-15.