Professor of Biology
Courses: Human Anatomy (BIO 290), Functional Neuroscience for Occupational Therapists (BIO 440/540), Clinical Anatomy for Occupational Therapists (BIO 414/514), Human Histology (BIO 482/582), Advanced Human Anatomy (BIO 410), Scientific Presentations (BIO 603)
Research Interests: Neurobiology and Anatomy of the auditory system.
Hearing is one of our most important senses and is ultimately the responsibility of the auditory system. Processing that occurs within the central auditory system enables us to unconsciously sort out meaningful sounds from background noise, to localize the source of sounds, and to determine whether a sound is noteworthy of our attention. These sophisticated auditory tasks that we perform routinely depend upon specialized neural circuits that compute subtle differences in the shape, timing, and intensity of stimuli as they independently arrive at each ear.
The circuitry underlying such complex auditory processing requires an elaborate organization. An ordered arrangement of inputs to an auditory center is essential since it not only preserves information that has been processed downstream, but it also provides the foundation for a neural network that is capable of integrating that information before it is relayed on to the next level of the system. The focus of the research in my laboratory is to understand the early development and organization of converging pathways in the ascending auditory system, as well as the developmental mechanisms that guide such circuit formation. To address these fundamental questions, my lab uses neuroanatomical techniques (namely fluorescent tract-tracing and immunohistochemistry) in the developing rat to simultaneously label separate pathways and neuronal populations (see images below). Understanding the development and organization of the auditory system is clinically important. To most effectively treat developmental hearing disorders, it is essential to understand the normal development of the system and the most appropriate time for intervention.
Wallace MM, Kavianpour SM, Gabriele ML. 2013. Ephrin-B2 reverse signaling is required for topography but not pattern formation of lateral superior olivary inputs to the inferior colliculus. J Comp Neurol. 521(7)1585-1597.
Gabriele ML, Brubaker DQ, Chamberlain KA, Kross KM, Simpson NS, Kavianpour SM. 2011. EphA4 and eprhin-B2 expression patterns during inferior colliculus projection shaping prior to experience. Developmental Neurobiology. 71:182-199.
Fathke RL, Gabriele ML. 2009. Patterning of multiple layered projections to the auditory midbrain prior to experience. Hearing Research. 249:36-43.
Gabriele ML, Smoot JE, Jiang H, Stein BE, and McHaffie JG. 2006. Early establishment of adult-like nigrotectal architecture in the neonatal cat: A double labeling study using carbocyanine dyes. Neuroscience 137(4):1309-1319.
Henkel CK, Gabriele ML, McHaffie JG. 2005. Quantitative assessment of developing afferent patterns in the cat inferior colliculus revealed with calbindin immunohistochemistry and tract tracing methods. Neuroscience 136(3):945-955.
McHaffie JG, Anstrom KK, Gabriele ML, and Stein BE. 2001. Distribution of the calcium binding proteins calbindin D-28k and parvalbumin in the superior colliculus of adult and newborn cat and rhesus monkey. Exp Brain Res 141:460-470.
Gabriele ML, Brunso-Bechtold JK, and Henkel CK. 2000. Plasticity in the development of afferent patterns in the inferior colliculus of the rat after unilateral cochlear ablation. J Neuroscience 20(18):6939-6949.
Gabriele ML, Brunso-Bechtold JK, and Henkel CK. 2000. Development of afferent patterns in the inferior colliculus of the rat: Projection from the dorsal nucleus of the lateral lemniscus. J Comp Neurol 416:368-382.