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Courses:
Cell and
Molecular Biology (214), Allied
Health Microbiology
(BIO 280), Advanced Molecular Biology (BIO 480)
Research Interests: Molecular Biology. Signal
Transduction and Nitric Oxide Synthase I in mammalian brain cells.
Mammalian brain development and our ability to
learn and remember
information requires the activation of a number of complex signaling
pathways. My current research interests involve finding which
factors in the Nerve Growth Factor induced signaling cascade are
responsible for increasing the expression of the enzyme, Nitric Oxide
Synthase I (NOS I). This enzyme
produces a free radical
gas, NO, and is upregulated during brain development and during
memory formation. Additionally, increased NOS I expression
occurs following stroke and neuronal injury and in many
neurodegenerative diseases with fatal consequences. Thus
learning the signaling pathway through which NOS I is upregulated may
have far reaching effects in our understanding disease, brain
development, and memory formation.
Selected
Publications:
T. K. Rife, J. Xie, C. Redman and A. P. Young,
"NGF-mediated
Induction of Nitric Oxide Synthase 1 Luciferase Fusion Genes Stably
Transformed into PC12 Cells," Brain Research. Molecular Brain
Research, vol. 75 pp.225-236, (2000)
A. P. Young, F. Murad, H. Vaessin, J. Xie, and T.
K. Rife,
"Transcription of the Human Neuronal Nitric Oxide Synthase Gene in
the Central Nervous System is Mediated by Multiple Promoters,"
Advances in Pharmacology, vol. 34 pp. 91-109, (1995)
J. Xie, P. Roddy, T. K. Rife, F. Murad, and A.
P. Young, "Two
closely linked but separable promoters for human neuronal nitric
oxide synthase gene transcription," Proc. Natl. Acad. Sci. USA., vol.
92, pp. 1242-1246, (1995)
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