|
Courses:
Cell and Molecular Biology (BIO 214), Animal Physiology (BIO 370),
Human Metabolism (BIO 472) and Human Metabolism lab (BIO 427).
Research Interests: Biochemistry
and molecular biology of
glucose transport across
membranes.
How do organisms use glucose? The hexose transporters of Arabidopsis thaliana
belong to a super-family of proteins called major facilitator proteins,
which have been identified in humans, plants and yeast. So far, of the
30 genes identified as being putative hexose transporters, 4 have been
experimentally characterized. Much work is yet to be done on this large
and prevalent class of proteins. Their functional diversity is thought
to contribute to the metabolism of sugars under the various internal
and external environmental conditions experienced by the organism. We
are currently in the process of describing a salt-resistant phenotype
of the developing root in seedlings of STP1 k/o plant. Our
hypothesis is that STP1 plays a role in regulating the osmotic balance
in the developing root. In addition, we show that the response of
the STP1 mutant to osmotic stress induced by salt is distinct from the
response to high concentrations of sugar. Projects in my lab include
the study of gene expression patterns to identify relevant
metabolic/signaling pathways and morphological characterization of the
developing roots of the STP1 knockout plant.
Selected
Publications:
Daniel, J.C., Tongen, A., Warne, D.P., Warne, P.
(2009). A 3D Nonlinear Anisoptropic Spherical Inflation Model for
Intracranial Saccular Aneurysm Elastodynamics. Mathematics and
Mechanics of Solids. doi:10.1177/1081286508100498. 1-20.
Neel, N., Creasy, B.M., Rankin, J.N., Pierce E.M,.
McCoy, M.E., Daner, R.H., Fowler, J.A., Daniel, J.C., and Lantz,
C.S. (2004). Absence of interleukin-3 does not affect the
severity of local and systemic anaphylaxis but does enhance eosinophil
infiltration in a mouse model of allergic peritonitis. Imm. Lett.
95(1) 37-44.
Musch MW, Bookstein C, Rocha F, Lucioni A, Ren H,
Daniel J, Xie Y, McSwine RL, Rao MC, Alverdy J, Chang EB. (2002).
Region-specific adaptation of apical Na/H exchangers after extensive
proximal small bowel resection. Am J Physiol Gastrointest Liver
Physiol Oct; 283(4):G975-85.
|
|
