Dri. Christopher Berndsen
Structure of human BST-2 with BST-2 antagonist Vpu
Dr. Christopher Berndsen, Department of Chemistry and Biochemistry at JMU, in collaboration with Dr. Carla Slebodnick, Department of Chemistry at Virginia Tech
This research project aims to determine the structure of a human anti-viral protein through collaboration between JMU and VT. The primary goal of the experiments in this project is to determine the crystal structure of the human protein BST2 in a complex with the HIV-1 genome. This project will move toward this goal in four stages that will ultimately develop data that will result in a high-resolution crystal structure which will provide insight into the mechanism of BST2. The research collaboration will also develop into a teaching and training collaboration of students in X-ray crystallography.